From wiki: An epidemic of organ failures devastates the planet. Panic erupts and scientists feverishly make plans for a massive organ harvest. Out of the tragedy, GeneCo, a multi-billion dollar biotech company, emerges. GeneCo provides organ transplantation for a profit. In addition to financing options, GeneCo reserves the right to implement default remedies, including repossession. For those who can't keep up with their organ payments, collection is the responsibility of "organ repo men", skilled assassins contracted by GeneCo, ordered to recover GeneCo's property by any means necessary.

At the heart of the story is Shilo Wallace (Alexa Vega), a 17 year-old girl with a rare blood disease. She has been kept locked up and protected in her house, where she is guarded from the outside world by her father, Nathan Wallace (Anthony Head). While Shilo struggles with her wish to leave the house and experience the outside world, Nathan struggles with his job as the repo man, and more specifically, his next target, a woman named Blind Mag (Sarah Brightman). Blind Mag was a friend of Nathan's now-deceased wife, and is Shilo's godmother.

The Largo family, consisting of GeneCo president Rotti (Paul Sorvino), his daughter Amber (Paris Hilton), and his two sons Luigi and Pavi (Bill Moseley and Nivek Ogre, respectively), have their own plans. Rotti is dying, and the three siblings bicker and fight about who is to take the role as head of GeneCo.

The stories intertwine and merge at the GeneCo opera.